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The thymosin beta 4 gene is strongly activated in neural tissues during early postimplantation mouse development.

作者信息

Carpinterio P, Anadón R, del Amo F F, Gómez-Márquez J

机构信息

Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Santiago de Compostela, Galicia, Spain.

出版信息

Neurosci Lett. 1995 Jan 16;184(1):63-6. doi: 10.1016/0304-3940(94)11169-j.

DOI:10.1016/0304-3940(94)11169-j
PMID:7739809
Abstract

We studied the temporal and spatial distribution of the mRNA encoding for thymosin beta 4 (T beta 4), a small acidic actin-sequestering peptide, during the early postimplantation mouse development. Analysis of total embryo RNA demonstrated a strong activation of T beta 4 gene after gastrulation and coincident with neurulation. In situ hybridization showed that T beta 4 mRNA was strongly expressed in the central nervous system and peripheral ganglia, paralleling the gradient of neuronal differentiation. An intense signal was also observed in intraventricular macrophages and blood vessels. The role of T beta 4 in mammalian neuroembryogenesis is discussed.

摘要

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引用本文的文献

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Identification of the positive and negative cis-elements involved in modulating the constitutive expression of mouse thymosin beta4 gene.参与调控小鼠胸腺素β4基因组成型表达的正负顺式作用元件的鉴定。
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The beta-thymosins, small actin-binding peptides widely expressed in the developing and adult cerebellum.
β-胸腺素是一类小的肌动蛋白结合肽，在发育中的小脑和成年小脑中广泛表达。
Cerebellum. 2002 Apr;1(2):95-102. doi: 10.1007/BF02941895.
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