Linoli O, Ventura P
U.O. di Anatomia, Presidio Ospedaliero della U.S.L. no 23, Arezzo.
Pathologica. 1994 Oct;86(5):513-24.
A histological analysis was performed on 3 cases of bronchiolo-alveolar carcinoma (BAC) in one of which an electronmicroscopic research was made. It was about a case of BAC with pneumonocytes of type I the lasting in life of which from the ascertainment of the tumor was 1.2 years (autopsy); and of a case of BAC with pneumocytes of type II (operatory case) and of a case of BAC with conventional cells (autoptic case) who survived an average of 4.3 years. All the cases had metastasis in the ilar lymph nodes. The three BAC were localized in the superficial area of the lung and it is also evident that they occupy the alveolar cavities, taking the thin alveolar wall as the only interstice. Besides in the following development there was evident tendency to hypertrophy of the interstizial collagen tissue, in the BAC with pneumocytes of type II and respectively with cells of conventional type; and the subtotal PAS negativity in the BAC with pneumocytes of type I. The included nuclears present in the only BAC with pneumocytes of the second type take the origin from the cytoplasm in the shape of small round masses penetrating into the nucleus, as from electronic microscopy. In the considered BAC, it was about surfactant apoproteins wich, in the nucleus, precipitate in morphologically different shapes.
对3例细支气管肺泡癌（BAC）进行了组织学分析，其中1例进行了电子显微镜研究。1例为I型肺上皮细胞的BAC病例，从确诊肿瘤到患者死亡持续了1.2年（尸检）；1例为II型肺上皮细胞的BAC病例（手术病例），1例为传统细胞型BAC病例（尸检病例），平均存活4.3年。所有病例均有肺门淋巴结转移。3例BAC均位于肺浅表区域，且明显占据肺泡腔，仅以薄的肺泡壁作为间隙。此外，在后续发展中，II型肺上皮细胞的BAC以及传统细胞型BAC中，间质胶原组织有明显的肥大趋势；I型肺上皮细胞的BAC中PAS反应呈弱阳性。仅在II型肺上皮细胞的BAC中观察到的核内包涵体，从电子显微镜观察来看，起源于细胞质，呈小圆形团块穿透入细胞核。在所研究的BAC中，存在表面活性物质载脂蛋白，其在细胞核中呈形态各异的沉淀。
