通过聚酸酐聚合物经壁释放肝素预防微血管手术中的静脉血栓形成。
Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer.
作者信息
Orloff L A, Glenn M G, Domb A J, Esclamado R A
机构信息
Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego Medical Center 92103-8891, USA.
出版信息
Surgery. 1995 May;117(5):554-9. doi: 10.1016/s0039-6060(05)80255-7.
BACKGROUND
The effects of transmurally released heparin on the patency of microvenous anastomoses were studied by using a bioerodible polymer delivery system in a rat microvascular thrombosis model.
METHODS
A polyanhydride carrier with heparin was wrapped around the outside of a highly thrombogenic venous inversion graft in 14 animals, and patency rates were compared with those of 17 control animals.
RESULTS
Anastomotic patency was significantly greater in the groups treated with transmurally released heparin, measured both at 24 hours (86% versus 16%; p < 0.02) and at 7 days (86% versus 36%; p < 0.05) after operation. No significant complications occurred.
CONCLUSIONS
Controlled release of heparin by transmural delivery is an effective and safe form of local antithrombotic therapy and may have applications both in microvascular and large vessel surgery.
背景
在大鼠微血管血栓形成模型中，通过使用生物可蚀性聚合物给药系统研究了经壁释放肝素对微静脉吻合口通畅性的影响。
方法
将含有肝素的聚酐载体包裹在14只动物高度致血栓形成的静脉反转移植物外部，并将通畅率与17只对照动物的通畅率进行比较。
结果
经壁释放肝素治疗组的吻合口通畅性明显更高，术后24小时（86%对16%；p<0.02）和7天时（86%对36%；p<0.05）均如此。未发生明显并发症。
结论
经壁给药控制肝素释放是一种有效且安全的局部抗血栓治疗形式，可能在微血管和大血管手术中均有应用。
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