Hauser I, Schneider B, Lechner K
First Dept. of Internal Medicine, University of Vienna, Austria.
Thromb Haemost. 1995 Jan;73(1):1-5.
In a retrospective study 51 published cases of post-partum factor VIII inhibitors were analyzed with regard to the outcome according to treatment. The overall outcome was favorable with 97% survival at two years. The probability of complete remission (CR, absence of the inhibitor and normalization of factor VIII activity) was almost 100% at 30 months. Steroid treatment appears to be not superior to no treatment, but patients treated with immunosuppressive drugs (cyclophosphamide, azathioprine, 6-mercaptopurine) had a significantly shorter time to CR. In the absence of a randomized trial this analysis may be helpful for decision-making in women with factor VIII post-partum inhibitors. Because of the retrospective study design, conclusions have to be regarded with caution.
在一项回顾性研究中，根据治疗情况对已发表的51例产后因子VIII抑制剂病例的结果进行了分析。总体结果良好，两年生存率为97%。30个月时完全缓解（CR，抑制剂消失且因子VIII活性正常化）的概率几乎为100%。类固醇治疗似乎并不优于不治疗，但接受免疫抑制药物（环磷酰胺、硫唑嘌呤、6-巯基嘌呤）治疗的患者达到CR的时间明显更短。在缺乏随机试验的情况下，该分析可能有助于产后因子VIII抑制剂女性患者的决策。由于采用回顾性研究设计，结论必须谨慎看待。
