Miller G J, Bauer K A, Barzegar S, Foley A J, Mitchell J P, Cooper J A, Rosenberg R D
Medical Research Council Epidemiology and Medical Care Unit, London, UK.
Thromb Haemost. 1995 Jan;73(1):82-6.
Effects of the quality and the time of venepuncture on factor VII coagulant activity (VIIc) and the concentrations of fibrinogen, prothrombin fragment 1 + 2 (F1 + 2) and fibrinopeptide A (FPA) were sought in 2665 men, of whom 2334 were re-examined after about one year. Venepunctures were categorised as satisfactory, not fully satisfactory or unsatisfactory according to pre-defined criteria. Neither the quality nor timing of the venepuncture influenced VIIc or fibrinogen concentration. However, at baseline and re-examination F1 + 2 and FPA were increased on average by about 9% and 45% respectively when venepunctures were not fully satisfactory, and by about 11% and 100% when unsatisfactory. Plasma collected after 1500 h had slightly but significantly lower levels of F1 + 2 and FPA than samples taken earlier, possibly due to circadian rhythm. The results emphasise the need for careful surveillance of the venepuncture procedure and the value of FPA when using F1 + 2 as a marker of risk of thrombosis.
在2665名男性中研究了静脉穿刺质量和时间对凝血因子VII促凝活性（VIIc）、纤维蛋白原浓度、凝血酶原片段1 + 2（F1 + 2）和纤维蛋白肽A（FPA）的影响，其中2334人在大约一年后接受了复查。根据预先定义的标准，静脉穿刺被分类为满意、不完全满意或不满意。静脉穿刺的质量和时间均未影响VIIc或纤维蛋白原浓度。然而，在基线和复查时，当静脉穿刺不完全满意时，F1 + 2和FPA平均分别增加约9%和45%，当不满意时分别增加约11%和100%。1500 h后采集的血浆中F1 + 2和FPA水平略低于但显著低于较早采集的样本，这可能归因于昼夜节律。结果强调了在使用F1 + 2作为血栓形成风险标志物时仔细监测静脉穿刺程序的必要性以及FPA的价值。
