Håheim L L, Holme I, Hjermann I, Leren P
Life Insurance Companies Institute of Medical Statistics, Ullevål Hospital, Oslo, Norway.
Stroke. 1995 May;26(5):774-7. doi: 10.1161/01.str.26.5.774.
The association between nonfasting serum glucose and stroke mortality for diabetic and nondiabetic subjects is presented for participants of the Oslo Study.
The study started in 1972; of 16,209 men aged 40 to 49 years, 16,172 had no previous history of stroke and 151 were known to be diabetic. Five diabetic and 80 nondiabetic subjects died of stroke during the 18 years of follow-up, giving a rate ratio of 7.87 (95% confidence interval [CI], 2.48 to 19.14). The rate of mortality for all causes in diabetic subjects was more than five times that of those who were nondiabetic.
Nonfasting serum glucose was a predictor of fatal stroke in all participants (diabetic subjects included) without a history of stroke in age-adjusted univariate analysis. The relative risk was 1.13 (CI, 1.03 to 1.25) by increase of 1 mmol/L of serum glucose according to results of proportional hazards regression analysis. Accordingly, relative risk for nondiabetic subjects was 1.02 (CI, 0.83 to 1.26) with no linear trend. The rate ratio of the fifth quintile to the rest was 1.57 (CI, 0.94 to 2.56) for all participants and 1.28 (CI, 0.72 to 2.18) for nondiabetics.
There was an interaction between glucose level and body mass index versus stroke for all participants but not for nondiabetic subjects, with an increased risk for men with above-median values of glucose and body mass index. Analysis of nondiabetic subjects failed to show glucose as a definite predictor of fatal stroke.
本文呈现了奥斯陆研究参与者中，非空腹血糖与糖尿病和非糖尿病受试者卒中死亡率之间的关联。
该研究始于1972年；在16209名40至49岁的男性中，16172人既往无卒中病史，151人已知患有糖尿病。在18年的随访期间，5名糖尿病患者和80名非糖尿病患者死于卒中，率比为7.87（95%置信区间[CI]，2.48至19.14）。糖尿病患者的全因死亡率是非糖尿病患者的五倍多。
在年龄调整的单因素分析中，非空腹血糖是所有无卒中病史参与者（包括糖尿病患者）致命性卒中的预测因素。根据比例风险回归分析结果，血清葡萄糖每升高1 mmol/L，相对风险为1.13（CI，1.03至1.25）。因此，非糖尿病受试者的相对风险为1.02（CI，0.83至1.26），无线性趋势。所有参与者中，第五分位数与其余分位数的率比为1.57（CI，0.94至2.56），非糖尿病患者为1.28（CI，0.72至2.18）。
对于所有参与者而言，血糖水平与体重指数和卒中之间存在相互作用，但非糖尿病受试者不存在这种相互作用，血糖和体重指数高于中位数的男性风险增加。对非糖尿病受试者的分析未能显示血糖是致命性卒中的明确预测因素。
