Katysheva O V, Novikova A V, Dlin V V, Ignatova M S, Klembovskiĭ A I, Barinskiĭ I F, Semenova T B, Posevaia T A, Shabalina N V, Brydun A V
Vopr Virusol. 1995 Jan-Feb;40(1):35-9.
A relationship between clinical forms of glomerulonephritis and incidence of viral antigens in renal tissue was revealed: Hepatitis B virus antigens (HBsAg) are more frequently detected in the glomeruli in the patients with nephrotic glomerulonephritis, Herpes simplex antigens are detected in the glomeruli in mixed glomerulonephritis, and cytomegaloviral and Herpes simplex antigens are detected in the epithelium of the proximal canaliculi in patients with hematuric glomerulonephritis. No correlations between the persistence of Herpes simplex type 1, cytomegalovirus, and HBsAg in the renal tissue were detected. HBsAg is detected in the renal tissue mainly in the children without free HBsAg in the blood serum. This may be indicative of an important role of specific immune complexes in the pathogenesis of glomerulonephritis associated with hepatitis B viral infection. The results point to an appreciable contribution of a persistent viral infection to the progress of glomerulonephritis.
在肾病性肾小球肾炎患者的肾小球中更频繁地检测到乙型肝炎病毒抗原（HBsAg）；在混合性肾小球肾炎患者的肾小球中检测到单纯疱疹抗原；在血尿性肾小球肾炎患者的近端小管上皮中检测到巨细胞病毒和单纯疱疹抗原。未检测到单纯疱疹病毒1型、巨细胞病毒和HBsAg在肾组织中的持续存在之间的相关性。HBsAg主要在血清中无游离HBsAg的儿童肾组织中检测到。这可能表明特异性免疫复合物在与乙型肝炎病毒感染相关的肾小球肾炎发病机制中起重要作用。结果表明持续性病毒感染对肾小球肾炎的进展有显著影响。
