Nagy J, Uj M, Szücs G, Trinn C, Burger T
Clin Nephrol. 1984 May;21(5):259-62.
Antibody titers against 4 viruses of the herpes group have been studied in the sera of 54 patients with IgA glomerulonephritis (GN). The incidence of antibodies to herpes simplex virus type-1 (HSV-1), HSV-2, cytomegalovirus (CMV), Epstein-Barr virus nuclear antigen (EBNA), and that of IgG antibodies to EBV virus capsid antigen (VCA) were similar in patients and in controls. However, elevated antibody titers (greater than or equal to 64) to HSV and CMV occurred more frequently in patients with IgA GN than in healthy controls. Geometric mean titers to HSV and CMV were also higher in patients suffering from IgA GN than in controls. The incidence of IgA antibodies to EBV VCA occurred in patients with IgA GN significantly more often than in controls. There was a trace amount of HSV-2 antigen in 2 glomeruli of 1 renal biopsy. It is concluded that, in some patients with IgA GN, there is an abnormal immune response to certain types of herpes viruses.
对54例IgA肾小球肾炎（GN）患者的血清进行了针对疱疹病毒组4种病毒的抗体滴度研究。1型单纯疱疹病毒（HSV-1）、2型单纯疱疹病毒（HSV-2）、巨细胞病毒（CMV）、EB病毒核抗原（EBNA）的抗体发生率以及EB病毒衣壳抗原（VCA）的IgG抗体发生率在患者和对照组中相似。然而，IgA GN患者中针对HSV和CMV的抗体滴度升高（大于或等于64）的情况比健康对照组更频繁。IgA GN患者中针对HSV和CMV的几何平均滴度也高于对照组。IgA GN患者中针对EBV VCA的IgA抗体发生率明显高于对照组。在1例肾活检的2个肾小球中有微量HSV-2抗原。得出的结论是，在一些IgA GN患者中，对某些类型的疱疹病毒存在异常免疫反应。
