Auble T E, Menegazzi J J, Paris P M
Division of Emergency Medicine, University of Pittsburgh School of Medicine, PA, USA.
Ann Emerg Med. 1995 May;25(5):642-8. doi: 10.1016/s0196-0644(95)70178-8.
Although some studies demonstrate otherwise, we hypothesized that metaanalysis would demonstrate a reduction in the relative risk of mortality when basic life support (BLS) providers can defibrillate out-of-hospital cardiac arrest patients.
Metaanalysis of studies meeting the following criteria: single-tier or two-tier emergency medical service (EMS) system, survival to hospital discharge for patients in ventricular fibrillation, and manual and/or automatic external defibrillators. The alpha error rate was .05.
Seven trials qualified for metaanalysis. Across all trials, the risk of mortality for BLS care with defibrillation versus that without was .915 (P = .0003). Separate subset analyses of single-tier and two-tier EMS systems demonstrated similar results.
BLS defibrillation can reduce the relative risk of death for out-of-hospital cardiac arrest victims in ventricular fibrillation. Weaknesses in individual study designs and regional clustering limit the strength of this metaanalysis and conclusion.
尽管一些研究得出了相反的结论，但我们假设，荟萃分析将表明，当基础生命支持（BLS）提供者能够对院外心脏骤停患者进行除颤时，死亡率的相对风险会降低。
对符合以下标准的研究进行荟萃分析：单层或两层紧急医疗服务（EMS）系统、心室颤动患者存活至出院、手动和/或自动体外除颤器。α错误率为0.05。
七项试验符合荟萃分析的条件。在所有试验中，有除颤的BLS护理与无除颤的BLS护理相比，死亡率风险为0.915（P = 0.0003）。对单层和两层EMS系统的单独亚组分析显示了相似的结果。
BLS除颤可降低心室颤动的院外心脏骤停受害者的相对死亡风险。个别研究设计的缺陷和区域聚类限制了该荟萃分析和结论的力度。
