Reznik V M, Griswold W R, Lemire J M, Mendoza S A
Department of Pediatrics, University of California School of Medicine, San Diego, California, USA.
Pediatr Nephrol. 1995 Feb;9(1):83-6. doi: 10.1007/BF00858982.
Pulmonary hemorrhage may occur in patients with immune-mediated glomerulonephritis. This association can be seen in a variety of disorders including systemic lupus erythematosus, vasculitis, Wegener's granulomatosis, anaphylactoid purpura and Goodpasture's syndrome. Immune mechanisms, such as immune complexes and/or autoantibodies, play a role in the pathogenesis of pulmonary and glomerular injury. Acute pulmonary hemorrhage can lead to respiratory failure and has a high mortality. Therapy with immunosuppressive agents such as pulse methylprednisolone and cyclophosphamide will control the hemorrhage and improve pulmonary function in most cases.
免疫介导性肾小球肾炎患者可能会发生肺出血。这种关联可见于多种疾病，包括系统性红斑狼疮、血管炎、韦格纳肉芽肿、过敏性紫癜和古德帕斯彻综合征。免疫机制，如免疫复合物和/或自身抗体，在肺和肾小球损伤的发病机制中起作用。急性肺出血可导致呼吸衰竭，死亡率很高。在大多数情况下，使用免疫抑制剂如静脉注射甲基强的松龙和环磷酰胺进行治疗可控制出血并改善肺功能。
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