编码烟草真核生物翻译起始因子eIF-4A的高度保守基因在功能基序上有特定改变。
Highly conserved genes coding for eukaryotic translation initiation factor eIF-4A of tobacco have specific alterations in functional motifs.
作者信息
Brander K A, Mandel T, Owttrim G W, Kuhlemeier C
机构信息
Institute of Plant Physiology, University of Berne, Altenbergrain, Switzerland.
出版信息
Biochim Biophys Acta. 1995 Apr 26;1261(3):442-4. doi: 10.1016/0167-4781(95)00052-i.
Eukaryotic translation initiation factor eIF-4A is an ATP-dependent RNA helicase that is required for the binding of mRNA to ribosomes. Plant eIF-4A-like proteins are highly homologous to eIF-4As from yeast, mouse and Drosophila melanogaster. The pattern of intron-exon boundaries in eIF-4A-like genes are conserved within tobacco, but are not conserved with other organisms. Fixed spacings between the functionally important sequence motifs, GKT-PTRELA (72 bp), DEAD-SAT (81 bp) and SAT-HRIGR (426 bp), are conserved between plants, mouse, Drosophila and yeast.
真核生物翻译起始因子eIF-4A是一种依赖ATP的RNA解旋酶，它是mRNA与核糖体结合所必需的。植物中类似eIF-4A的蛋白质与酵母、小鼠和果蝇的eIF-4A高度同源。烟草中类似eIF-4A的基因的内含子-外显子边界模式是保守的，但与其他生物不保守。植物、小鼠、果蝇和酵母之间，功能重要的序列基序GKT-PTRELA（72 bp）、DEAD-SAT（81 bp）和SAT-HRIGR（426 bp）之间的固定间距是保守的。
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