McAlister F, McClean K, Hamilton P G, Houston S
Department of Medicine, University of Alberta Hospital, Edmonton, Canada.
Clin Infect Dis. 1995 Feb;20(2):348-51. doi: 10.1093/clinids/20.2.348.
Several recent reports have described an association between human immunodeficiency virus (HIV) infection and porphyria cutanea tarda (PCT). We describe two HIV-infected patients who developed PCT and review 29 other reported cases of coexistent PCT and infection due to HIV. Recognized porphyrinogenic factors were identified in our patients and in 27 of the 29 cases described in the literature. Even in the two cases that lacked obvious precipitant factors for PCT, the possibility of hepatitis C was not excluded. This fact suggests that the co-occurrence of PCT and infection due to HIV may reflect the coexistence of risk factors for the two diseases rather than a causal association. Despite concern that exposure to sulfonamides might exacerbate porphyria, one of our patients and three patients described in the literature were safely treated with sulfonamides.
最近的几份报告描述了人类免疫缺陷病毒（HIV）感染与迟发性皮肤卟啉症（PCT）之间的关联。我们描述了两名发生PCT的HIV感染患者，并回顾了其他29例PCT与HIV感染共存的报告病例。在我们的患者以及文献中描述的29例病例中的27例中，确定了公认的卟啉生成因素。即使在两例缺乏明显PCT诱发因素的病例中，丙型肝炎的可能性也未被排除。这一事实表明，PCT与HIV感染的同时出现可能反映了这两种疾病危险因素的共存，而非因果关联。尽管担心接触磺胺类药物可能会加重卟啉症，但我们的一名患者以及文献中描述的三名患者接受磺胺类药物治疗后情况良好。
