Adler G, Pacuszka T, Targonska I, Lewartowska A, Nauman J
Department of Biochemistry, Medical Center of Postgraduate Education, Warsaw, Poland.
Autoimmunity. 1994;18(2):149-52. doi: 10.3109/08916939409007989.
In Graves' disease an increased immunological activity against glycoconjugate antigens is observed. Since gangliosides seem to be important for thyroid stimulation we searched for the presence of antiganglioside antibodies in Graves' patients sera by the immunoenzymatic method. Antibodies against some of 12 different gangliosides used in this study were found in 22% of the patients. However, in most cases the titer of antiganglioside antibodies was very low. Only the serum from one patient reacted with FucGM1 ganglioside at the dilution up to 1:1300. Anti-FucGM1 antibodies were present in serum samples of this patient taken before and during the treatment when she was hyper-hypo- and euthyroid. The lack of relation of the anti-FucGM1 antibody titer to the thyroid status of this patient, and the very low titer of antiganglioside antibodies in sera of some other patients, suggest that the presence of these antibodies has no close connection to the thyroid disease.
在格雷夫斯病中，观察到针对糖缀合物抗原的免疫活性增加。由于神经节苷脂似乎对甲状腺刺激很重要，我们通过免疫酶法寻找格雷夫斯病患者血清中抗神经节苷脂抗体的存在。在本研究中使用的12种不同神经节苷脂中的一些抗体，在22%的患者中被发现。然而，在大多数情况下，抗神经节苷脂抗体的滴度非常低。只有一名患者的血清在高达1:1300的稀释度下与FucGM1神经节苷脂发生反应。该患者在治疗前、治疗期间甲状腺功能亢进、减退和正常时采集的血清样本中均存在抗FucGM1抗体。该患者抗FucGM1抗体滴度与甲状腺状态缺乏相关性，以及其他一些患者血清中抗神经节苷脂抗体滴度非常低，表明这些抗体的存在与甲状腺疾病没有密切联系。
