Konoshima T, Takasaki M, Kozuka M, Nagao T, Okabe H, Irino N, Nakasumi T, Tokuda H, Nishino H
Kyoto Pharmaceutical University, Japan.
Biol Pharm Bull. 1995 Feb;18(2):284-7. doi: 10.1248/bpb.18.284.
To search for possible anti-tumor-promoters, we carried out a primary screening of twenty-four 29-nor-cucurbitacin glucosides isolated from the roots of Cayaponia tayuya (Cucurbitaceae) using an in vitro synergistic assay system. Of these glucosides, cayaponosides B (5), B3 (7), D (8), D3b (22) and C2 (23) exhibited significant inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, 5 and 23 exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
