Rusch V W, Dmitrovsky E
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Chest Surg Clin N Am. 1995 Feb;5(1):39-55.
A fuller understanding of the fundamental mechanisms involved in tumor initiation, growth, and metastasis will enable us to develop innovative approaches to detection and treatment that will improve the poor survival of patients with lung cancer. Current information suggests that certain individuals may be predisposed to developing lung cancer and that lung cancers, like other solid tumors, are characterized by the activation of oncogenes, the expression of growth factor loops, and the inactivation of tumor suppressor genes. Within the next decade, it is likely that genetic abnormalities will be used to identify individuals at risk for lung cancer, to select patients for adjuvant therapy, and to develop novel forms of treatment.
对肿瘤起始、生长和转移所涉及的基本机制有更全面的了解，将使我们能够开发出创新的检测和治疗方法，从而改善肺癌患者较差的生存率。目前的信息表明，某些个体可能易患肺癌，而且肺癌与其他实体瘤一样，其特征在于癌基因的激活、生长因子环的表达以及肿瘤抑制基因的失活。在未来十年内，基因异常很可能会被用于识别肺癌高危个体、选择辅助治疗的患者以及开发新的治疗形式。
