窒息新生儿的神经元特异性烯醇化酶：与脑病及脑功能监测轨迹的关联
Neuron specific enolase in asphyxiated newborns: association with encephalopathy and cerebral function monitor trace.
作者信息
Thornberg E, Thiringer K, Hagberg H, Kjellmer I
机构信息
Department of Paediatric Anaesthesia and Intensive Care, Göteborg University, Sweden.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1995 Jan;72(1):F39-42. doi: 10.1136/fn.72.1.f39.
Abstract
Neuron specific enolase (NSE) in serum and cerebrospinal fluid (CSF) and glutamate in CSF were investigated in the immediate postasphyctic period in 22 term newborn infants. The cerebral function monitor (CFM) pattern was also assessed and hypoxic-ischaemic encephalopathy (HIE) was graded. NSE was significantly increased in the CSF of infants with HIE (median value 25.4 micrograms/l) compared with control infants (10.0 micrograms/l). Infants with the highest concentrations died. NSE in CSF correlated with the degree of asphyxial damage. Glutamate and NSE in CSF did not correlate, presumably due to the different time factors of the release after the insult. NSE in CSF corresponded well with the type of CFM pattern, which was also highly predictive of outcome.
摘要
对22名足月儿在窒息后即刻的血清和脑脊液（CSF）中的神经元特异性烯醇化酶（NSE）以及脑脊液中的谷氨酸进行了研究。同时评估了脑功能监测仪（CFM）模式，并对缺氧缺血性脑病（HIE）进行了分级。与对照组婴儿（10.0微克/升）相比，HIE婴儿脑脊液中的NSE显著升高（中位数为25.4微克/升）。NSE浓度最高的婴儿死亡。脑脊液中的NSE与窒息损伤程度相关。脑脊液中的谷氨酸和NSE不相关，可能是由于损伤后释放的时间因素不同。脑脊液中的NSE与CFM模式类型高度相符，CFM模式对预后也具有高度预测性。
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