Palmer L S, Laor E, Skinner W K, Tolia B M, Reid R E, Freed S Z
Department of Urology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, N.Y., USA.
Eur Urol. 1995;27(2):96-8. doi: 10.1159/000475136.
We performed a prospective study to evaluate fine-needle aspiration (FNA) cytology as a screening tool of carcinoma of the prostate in 159 men with normal digital rectal examinations and acid phosphatase prior to open prostatectomy for voiding symptoms. The incidence of carcinoma of the prostate was 5.6%. 4 patients had A1 lesions and 5 had A2 lesions. Only one A2 lesion was malignant cytologically. The sensitivity was 56%, specificity 69%, positive predictive value 24% and negative predictive value 90%. Sufficient cytologic specimens were provided in 66% of cases. While FNA is at least equal to core biopsy as a diagnostic modality of palpable prostatic abnormalities, it does not prove to be an adequate screening modality for occult carcinoma of the prostate in the prostatectomy candidate.
我们进行了一项前瞻性研究，以评估细针穿刺（FNA）细胞学检查作为前列腺癌筛查工具的效果。研究对象为159名因排尿症状接受开放性前列腺切除术，直肠指检和酸性磷酸酶检查均正常的男性。前列腺癌的发病率为5.6%。4例患者为A1期病变，5例为A2期病变。只有1例A2期病变在细胞学上为恶性。敏感性为56%，特异性为69%，阳性预测值为24%，阴性预测值为90%。66%的病例提供了足够的细胞学标本。虽然FNA作为一种可触及前列腺异常的诊断方法至少与穿刺活检相当，但它并未被证明是一种适用于前列腺切除候选者隐匿性前列腺癌的充分筛查方法。
