Moreira L F, Aires S T, Gobbi C F, Saldiva P H, Zin W A
Instituto de Biofisica Carlos Chagas Filho, UFRJ, Ilha do Fundão, Rio de Janeiro, Brazil.
Eur Respir J. 1995 Jan;8(1):105-8. doi: 10.1183/09031936.95.08010105.
It has been demonstrated that respiratory resistance and elastance increase whilst the abdomen remains open during longitudinal laparotomy. We wished to determine whether changes also occur after abdominal closure in the same animal preparation. In 10 sedated, anaesthetized paralysed, and mechanically-ventilated rats (309 +/- 33 (SD) g), resistances and elastances of the respiratory system, lung, and chest wall were measured both before longitudinal laparotomy and directly after abdominal closure. Furthermore, the resistances were also split into their initial and difference components, the former reflecting the Newtonian resistances and the latter representing the viscoelastic/inhomogeneous pressure dissipations in the system. For this purpose, the end inflation occlusion during constant inspiratory flow method was used. After laparotomy, no statistically significant changes were found in elastances and resistances of the respiratory system, lungs and chest wall (paired Student's t-test, significance level = 5%). It can be concluded that after midline xiphipubic laparotomy accompanied by bilateral ventro-dorsal infracostal incision, respiratory resistances and elastances were not different from those found in the control condition.
已有研究表明，在纵向剖腹手术期间腹部保持开放时，呼吸阻力和弹性会增加。我们希望确定在同一动物模型中腹部闭合后是否也会发生变化。在10只经镇静、麻醉、麻痹并进行机械通气的大鼠（体重309±33（标准差）克）中，在纵向剖腹手术前和腹部闭合后直接测量呼吸系统、肺和胸壁的阻力和弹性。此外，阻力还被分为初始分量和差值分量，前者反映牛顿阻力，后者代表系统中的粘弹性/非均匀压力耗散。为此，采用了恒定吸气流量法下的终末充气阻断法。剖腹手术后，呼吸系统、肺和胸壁的弹性和阻力未发现统计学上的显著变化（配对学生t检验，显著性水平=5%）。可以得出结论，在进行中线剑突耻骨剖腹手术并伴有双侧腹背肋下切口后，呼吸阻力和弹性与对照条件下无异。
