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Insulin receptor tyrosine-kinase activity is altered in both muscle and adipose tissue from non-obese normoglycaemic insulin-resistant subjects.

作者信息

Grasso G, Frittitta L, Anello M, Russo P, Sesti G, Trischitta V

机构信息

Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, Italy.

出版信息

Diabetologia. 1995 Jan;38(1):55-61. doi: 10.1007/BF02369353.

DOI:10.1007/BF02369353
PMID:7744230
Abstract

We performed i.v. insulin tolerance test in 30 non-obese (BMI < 30 male and < 28 female) non-diabetic (by oral glucose tolerance test) subjects and subdivided them into three groups of 10 subjects each, according to their insulin sensitivity (K(itt) values). Then we compared the tyrosine-kinase activity of immunopurified insulin receptors (using 32P-ATP and poly-glu-tyr (4:1) from both muscle and adipose tissue in 7 of the most insulin-sensitive and 7 of the most insulin-resistant subjects. No difference was observed between the two groups in the basal (no insulin) receptor tyrosine-kinase activity from both tissues. In contrast, tyrosine-kinase activity response to insulin was significantly higher (p < 0.05 by 2-way ANOVA test) in receptors from both tissues of insulin-sensitive subjects. In addition, a decreased tyrosine-kinase sensitivity to insulin was observed in muscle, but not adipose, tissue of insulin-resistant subjects (insulin ED50 being 0.87 +/- 0.05 nmol/l vs 2.03 +/- 0.07, p < 0.05 in insulin-sensitive and -resistant subjects). Insulin ED50 of muscle receptor tyrosine-kinase significantly (p = 0.001) correlated to both K(itt) values (r = -0.79) and plasma insulin values at 120 min during OGTT (r = + 0.80). Insulin receptor content, as assessed by radioimmunoassay, was similar in both muscle (7.9 +/- 1.3 and 9.2 +/- 1.9 ng/mg protein) and adipose tissue (8.2 +/- 1.3 and 7.5 +/- 1.4) of insulin-sensitive and -resistant subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

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3
Insulin action in skeletal muscle from patients with NIDDM.非胰岛素依赖型糖尿病患者骨骼肌中的胰岛素作用。

本文引用的文献

1
Role of the exon 11 of the insulin receptor gene on insulin binding identified by anti-peptide antibodies.抗肽抗体鉴定胰岛素受体基因外显子11在胰岛素结合中的作用。
Mol Cell Endocrinol. 1994 May;101(1-2):121-7. doi: 10.1016/0303-7207(94)90226-7.
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Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus.2型(非胰岛素依赖型)糖尿病患者年轻、非肥胖一级亲属肌肉中部分纯化的胰岛素受体酪氨酸激酶活性降低。
Diabetologia. 1993 Jul;36(7):668-74. doi: 10.1007/BF00404079.
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Relationship between insulin receptor tyrosine kinase activity and internalization in monocytes of non-insulin-dependent diabetes mellitus patients.
Mol Cell Biochem. 1998 May;182(1-2):153-60.
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PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity.非肥胖、非糖尿病受试者骨骼肌中的PC-1含量:与胰岛素受体酪氨酸激酶及全身胰岛素敏感性的关系。
Diabetologia. 1996 Oct;39(10):1190-5. doi: 10.1007/BF02658505.
5
Effects of exercise training on abdominal obesity and related metabolic complications.运动训练对腹部肥胖及相关代谢并发症的影响。
Sports Med. 1996 Mar;21(3):191-212. doi: 10.2165/00007256-199621030-00004.
Metabolism. 1993 Jul;42(7):882-7. doi: 10.1016/0026-0495(93)90064-u.
4
Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects.2型(非胰岛素依赖型)糖尿病患者骨骼肌膜中胰岛素受体亚型模式的改变。
Diabetologia. 1993 Jul;36(7):628-32. doi: 10.1007/BF00404072.
5
Insulin receptor tyrosine kinase activity is reduced in monocytes from non-obese normoglycaemic insulin-resistant subjects.非肥胖血糖正常胰岛素抵抗受试者的单核细胞中,胰岛素受体酪氨酸激酶活性降低。
Diabetologia. 1993 Nov;36(11):1163-7. doi: 10.1007/BF00401061.
6
Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein.人胰岛素受体蛋白两种可变剪接异构体的组织特异性表达。
Acta Diabetol. 1994 Jun;31(2):59-65. doi: 10.1007/BF00570536.
7
Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes.胰岛素受体亚型表达与非胰岛素依赖型糖尿病风险相关。
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2633-5. doi: 10.1073/pnas.90.7.2633.
8
Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes.II型糖尿病患者胰岛素结合与胰岛素刺激的酪氨酸激酶活性之间的关系发生了改变。
J Clin Invest. 1987 Feb;79(2):453-62. doi: 10.1172/JCI112833.
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Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.非胰岛素依赖型糖尿病患者脂肪细胞中胰岛素受体的激酶活性降低。
J Clin Invest. 1987 Jan;79(1):240-50. doi: 10.1172/JCI112789.
10
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.非胰岛素依赖型糖尿病患者肝脏胰岛素抵抗机制的研究。分离肝细胞中的胰岛素作用与结合、胰岛素受体结构及激酶活性。
J Clin Invest. 1986 Jul;78(1):249-58. doi: 10.1172/JCI112558.