Sela B A, Hassin-Baer S, Goldhamer Y, Polak-Charcon S, Nass D, Duvdevani P, Shulman L
Dept. of Neurology, Chaim Sheba Medical Center, Tel Hashomer.
Harefuah. 1995 Mar 1;128(5):273-6, 336, 335.
A 25-year-old man was admitted following deterioration in behavior and onset of blindness. He soon became comatose and died 6 weeks later. Brain biopsy showed nuclear inclusion bodies resembling viral capsids, astrocytosis and perivascular lymphocytic cuffing but no demyelination. The diagnosis of subacute sclerosing panencephalitis was made on finding: measles virus antigens in both serum and cerebrospinal fluid, the identification of measles RNA sequences in brain tissue by the polymerase chain reaction, and intense, oligoclonal, IgG-banding in the CSF. However, the relatively advanced age of the patient, the absence of myoclonus and the nondistinctive EEG profile lacking synchronous bursts of high-voltage slow and sharp waves, are unusual.
一名25岁男性在行为恶化和失明后入院。他很快陷入昏迷，6周后死亡。脑活检显示有类似病毒衣壳的核内包涵体、星形细胞增多和血管周围淋巴细胞套袖状浸润，但无脱髓鞘现象。根据以下检查结果确诊为亚急性硬化性全脑炎：血清和脑脊液中均发现麻疹病毒抗原，通过聚合酶链反应在脑组织中鉴定出麻疹RNA序列，以及脑脊液中出现强烈的寡克隆IgG带。然而，患者相对较高的年龄、无肌阵挛以及脑电图表现不典型，缺乏同步的高电压慢波和尖波爆发，这些情况并不常见。
