Hong Z, Li Z, Wang Y, Li L, Qiang W, Wang M, Zou J
Military School of Chengdu Surgeon.
Hua Xi Yi Ke Da Xue Xue Bao. 1994 Dec;25(4):410-3.
The concentrations of acetaminophen in human plasma were determined by RP-HPLC after administration of a single oral dose of 1000 mg acetaminophen oral drop or tablet to eight normal male volunteers in a crossover study. The concentration vs time curves of acetaminophen all fitted the two compartment model. The Cmax in oral drop and tablet were 11.23 +/- 0.93 and 8.79 +/- 0.93mg/L, respectively; Tmax were 0.86 +/- 0.08 and 1.48 +/- 0.39h; T1/2 beta 3.03 +/- 0.79 and 2.51 +/- 1.10 h; AUC 42.35 +/- 6.20 and 40.60 +/- 6.79mg/L.h. When AUC in tablet was 100%, the relative bioavailability of acetaminophen oral drop was 105.58%. The results showed that the oral drop and tablet are bioequivalent.
在一项交叉研究中，给8名正常男性志愿者单次口服1000mg对乙酰氨基酚口服滴剂或片剂后，采用反相高效液相色谱法测定人血浆中对乙酰氨基酚的浓度。对乙酰氨基酚的浓度-时间曲线均符合二室模型。口服滴剂和片剂的Cmax分别为11.23±0.93和8.79±0.93mg/L；Tmax分别为0.86±0.08和1.48±0.39小时；T1/2β分别为3.03±0.79和2.51±1.10小时；AUC分别为42.35±6.20和40.60±6.79mg/L·h。以片剂的AUC为100%时，对乙酰氨基酚口服滴剂的相对生物利用度为105.58%。结果表明口服滴剂和片剂生物等效。
