[不同肾癌细胞原代培养物的免疫调节作用]
[Primary culture of different renal cell carcinoma cells with respect to immunomodulatory effects].
作者信息
Knöfel B, Junker U, Nuske K, el-Seweifi A, Junker K, Kosmehl H, Jäger L
机构信息
Institut für Klinische Immunologie, Universität Jena.
出版信息
Immun Infekt. 1995 Apr;23(2):72-3.
The presented results show that renal cell carcinomas (RCC) have partial immunomodulatory capacity (production of cytokines as IL-6, -10, -11; modulation of mitogen-induced transformation of T lymphocytes). The production of IL-10 shows a tendency to correlate with higher staging and grading of RCC. The cytokine production does not correlate with specific types of RCC. Direct immunosuppression of T lymphocytes in lymphocyte transformation tests (LTT) was not detectable.
所呈现的结果表明，肾细胞癌（RCC）具有部分免疫调节能力（产生如IL-6、-10、-11等细胞因子；调节丝裂原诱导的T淋巴细胞转化）。IL-10的产生显示出与RCC的更高分期和分级相关的趋势。细胞因子的产生与RCC的特定类型无关。在淋巴细胞转化试验（LTT）中未检测到对T淋巴细胞的直接免疫抑制。
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