Teske E, van Heerde P, Rutteman G R, Kurzman I D, Moore P F, MacEwen E G
Department of Clinical Sciences of Companion Animals, Utrecht University, The Netherlands.
J Am Vet Med Assoc. 1994 Dec 15;205(12):1722-8.
Pretreatment characteristics of 138 dogs with malignant lymphoma were analyzed to determine prognostic factors associated with outcome (ie, complete response rate, time to relapse after complete response, survival time). Dogs were all treated for 10 weeks, using a standard induction chemotherapy protocol, and were then given asparaginase weekly. Once the disease became progressive, second-line chemotherapy was instituted. Age, sex, weight, clinical stage, performance grade, immunophenotype, and malignancy grade assigned according to the National Cancer Institute's Working Formulation were not associated with complete response rate. However, malignancy grade assigned according to the Kiel classification was found to be associated with complete response rate; dogs with high-grade malignancies had a significantly higher complete response rate than did dogs with low-grade malignancies. By means of multivariate analysis, clinical stage and immunophenotype were found to be prognostic factors for time to relapse (among dogs that had had a complete response) and survival time. In addition, malignancy grade assigned according to the Kiel classification was found to be a prognostic factor for time to relapse; whereas, malignancy grade assigned according to the Working Formulation was determined to be a prognostic factor for survival time.
分析了138只患有恶性淋巴瘤的犬的预处理特征，以确定与预后相关的因素（即完全缓解率、完全缓解后复发时间、生存时间）。所有犬均采用标准诱导化疗方案治疗10周，然后每周给予天冬酰胺酶。一旦疾病进展，即开始二线化疗。根据美国国立癌症研究所工作分类法确定的年龄、性别、体重、临床分期、表现评分、免疫表型和恶性程度与完全缓解率无关。然而，根据基尔分类法确定的恶性程度与完全缓解率相关；高级别恶性肿瘤的犬的完全缓解率显著高于低级别恶性肿瘤的犬。通过多变量分析，发现临床分期和免疫表型是（完全缓解的犬中）复发时间和生存时间的预后因素。此外，根据基尔分类法确定的恶性程度是复发时间的预后因素；而根据工作分类法确定的恶性程度则被确定为生存时间的预后因素。
