Galbreath E, Kim S J, Park K, Brenner M, Messing A
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, USA.
J Neuropathol Exp Neurol. 1995 May;54(3):339-49. doi: 10.1097/00005072-199505000-00007.
Transforming growth factor beta (TGF-beta) has been proposed to play a number of roles in central nervous system (CNS) development and response to injury. To test these proposals, transgenic mice were generated which overproduce TGF-beta 1 in the CNS. Surprisingly, these mice developed severe hydrocephalus and died between birth and 3 weeks of age. Ovary transplantation from an affected female founder has permitted perpetuation of one of the lines as a hydrocephalus model whose genetic defect is known. These results also demonstrate that the developing CNS is highly sensitive to TGF-beta, and suggest a role for aberrant expression of TGF-beta in the pathogenesis of developmental disease of the CNS.
转化生长因子β（TGF-β）已被提出在中枢神经系统（CNS）发育和损伤反应中发挥多种作用。为了验证这些说法，研究人员培育了在中枢神经系统中过量产生TGF-β1的转基因小鼠。令人惊讶的是，这些小鼠出现了严重的脑积水，并在出生至3周龄之间死亡。从受影响的雌性奠基者进行卵巢移植，使得其中一个品系得以延续，成为一种已知遗传缺陷的脑积水模型。这些结果还表明，发育中的中枢神经系统对TGF-β高度敏感，并提示TGF-β异常表达在中枢神经系统发育性疾病发病机制中的作用。
