Terada H, Matsumoto S, Nakamura K, Miyazawa K
Department of Anesthesiology, Hiraka General Hospital, Yokote.
Masui. 1995 Mar 3;44(3):314-8.
In this study, we used transesophageal echocardiography to investigate the effect of isoflurane (0.0, 0.3, 0.5, and 1.0%) on cardiac systolic and diastolic function in 10 adult patients without ischemic heart disease. Concerning systolic function, fractional shortening, stroke volume, and cardiac output showed dose-dependent, significant increases at 1% isoflurane. Concerning diastolic function, left ventricular flow velocity and pulmonary vein flow velocity were measured but the peak velocities were unchanged at each concentration of isoflurane. In conclusion, isoflurane at concentrations used in the current study is unlikely to cause significant myocardial depression in normal adults.
在本研究中，我们使用经食管超声心动图来研究异氟烷（0.0%、0.3%、0.5%和1.0%）对10例无缺血性心脏病的成年患者心脏收缩和舒张功能的影响。关于收缩功能，在1%异氟烷时，缩短分数、每搏输出量和心输出量呈剂量依赖性显著增加。关于舒张功能，测量了左心室血流速度和肺静脉血流速度，但在各浓度异氟烷下峰值速度均未改变。总之，本研究中使用的浓度的异氟烷不太可能在正常成年人中引起显著的心肌抑制。
