Morishita T, Mii Y, Miyauchi Y, Miura S, Honoki K, Aoki M, Kido A, Tamai S, Tsutsumi M, Konishi Y
Department of Orthopedic Surgery, Nara Medical University, Kashihara.
Jpn J Clin Oncol. 1995 Apr;25(2):25-31.
The efficacy of the anti-angiogenic agent, O-(chloroacetyl-carbamoyl)fumagillol (AGM-1470), against primary tumor growth and spontaneous lung metastasis was evaluated experimentally using a transplantable osteosarcoma line in rats previously established in our laboratory. Male Fischer 344 rats bearing the tumor with a high potential for metastasis received intermittent or continuous subcutaneous administrations of AGM-1470. Both treatment regimens resulted in significant inhibitions of spontaneous lung metastasis and primary tumor growth in a dose-dependent manner, with continuous administration of AGM-1470 exerting the most pronounced inhibitory effects on both parameters.
使用我们实验室先前建立的可移植性骨肉瘤大鼠模型，对抗血管生成剂O-(氯乙酰-氨基甲酰)烟曲霉素(AGM-1470)抑制原发性肿瘤生长和自发性肺转移的效果进行了实验评估。携带高转移潜能肿瘤的雄性Fischer 344大鼠接受了AGM-1470的间歇性或连续性皮下给药。两种治疗方案均以剂量依赖方式显著抑制了自发性肺转移和原发性肿瘤生长，其中AGM-1470的连续给药对这两个参数的抑制作用最为明显。
