Fang Z, Yokoyama R, Mukai K, Beppu Y, Fukuma H
Department of Orthopedic Surgery, National Cancer Center Hospital, Tokyo.
Jpn J Clin Oncol. 1995 Apr;25(2):55-60.
Four cases of extraskeletal osteosarcoma which were treated at the National Cancer Center Hospital have been reviewed. There were three males and one female. The ages of the patients were 32, 48, 48 and 59 years. Three patients had a solitary tumor located in the lower leg, thigh or postirradiated abdominal wall. The remaining patient had multiple tumors in the ipsilateral thigh and buttock. The predominant histologic subtype was osteoblastic in two cases, chondroblastic in one and malignant fibrous histiocytoma-like in one. Only one patient with a subcutaneous tumor was free of disease 16 years after a wide local excision without chemotherapy. The other three patients, two having undergone inadequate initial surgery, and one with multiple tumors, developed pulmonary metastases within 24 months of their initial surgical treatment. All of them died of the pulmonary metastases eight, 36 and 63 months after their initial treatment. Postoperative intensive chemotherapy was given to two patients. Although both had developed metastases to the lung, they received resection of the metastases combined with additional chemotherapy, surviving for more than 24 months after the occurrence of their first metastases.
对在国立癌症中心医院接受治疗的4例骨外骨肉瘤病例进行了回顾。其中男性3例，女性1例。患者年龄分别为32岁、48岁、48岁和59岁。3例患者有单个肿瘤，分别位于小腿、大腿或放疗后的腹壁。其余1例患者在同侧大腿和臀部有多个肿瘤。主要组织学亚型为成骨细胞型2例，软骨母细胞型1例，恶性纤维组织细胞瘤样1例。仅1例皮下肿瘤患者在广泛局部切除且未进行化疗后16年无疾病。其他3例患者，2例初始手术不充分，1例有多个肿瘤，在初始手术治疗后24个月内发生肺转移。他们均在初始治疗后8个月、36个月和63个月死于肺转移。2例患者术后接受了强化化疗。尽管两人都已发生肺转移，但他们接受了转移灶切除并联合额外化疗，在首次转移发生后存活超过24个月。
