Chabior M
Department of the Pediatric Institute, Medical School of Gdańsk, Poland.
Mater Med Pol. 1994 Apr-Jun;26(2):49-53.
The initial stage of infection is characterized by both, changes in leucocyte function and humoral factors activity. In this paper we evaluated random migration and chemotaxis of neutrophils and serum ability to generate humoral factors influencing the neutrophil function. The studies were performed in 51 neonates during the acute phase of bacterial infection and in the remission time. Both random migration and chemotaxis were decreased during the acute phase of disease and normalized during remission. The same was true for serum ability to generate chemotactic activity. The serum of sick neonates did not alter the mobility of neutrophils isolated from adult healthy donors and it did not influence the normal chemotactic activity. We conclude, that the handicapped locomotive abilities of neutrophils in bacterial infection are temporary, and may require in severely ill infants supportive therapy to maintain adequate cellular and humoral immunity.
感染的初始阶段的特征是白细胞功能和体液因子活性均发生变化。在本文中，我们评估了中性粒细胞的随机迁移和趋化性以及血清产生影响中性粒细胞功能的体液因子的能力。研究在51例新生儿细菌感染急性期和缓解期进行。疾病急性期随机迁移和趋化性均降低，缓解期恢复正常。血清产生趋化活性的能力也是如此。患病新生儿的血清不会改变从成年健康供体分离的中性粒细胞的迁移能力，也不会影响正常的趋化活性。我们得出结论，细菌感染中中性粒细胞的运动能力受损是暂时的，对于重症婴儿可能需要支持治疗以维持足够的细胞免疫和体液免疫。
