Hill H R, Gerrard J M, Hogan N A, Quie P G
J Clin Invest. 1974 Apr;53(4):996-1002. doi: 10.1172/JCI107666.
To determine if changes in neutrophil leukocyte function occur during active bacterial infection, the neutrophils of 25 patients with active bacterial infection and 25 age-matched controls were compared for leukotactic activity, random mobility, and nitroblue tetrazolium reduction. The neutrophil leukocytes of patients with bacterial infection were hyperactive in unidirectional movement toward a chemotactic stimulus as measured in the leukotactic assay and usually had increased nitroblue tetrazolium reduction. The mean leukotactic index was 165+/-56 in patients with bacterial infection and 70+/-11 in controls (P < 0.001). After 7-10 days of appropriate therapy with clinical and bacteriological response, leukotactic activity returned to normal values. A hyperactive leukotactic response continued, however, in patients with persisting bacterial infection. The hyperactive leukotactic response of circulating neutrophils appears to be an early and sensitive event in the inflammatory cycle stimulated by bacterial infection and may aid in the localization of invading bacteria.
为了确定在活动性细菌感染期间中性粒细胞功能是否发生变化，对25例活动性细菌感染患者和25例年龄匹配的对照者的中性粒细胞进行趋化活性、随机移动性和硝基蓝四氮唑还原试验的比较。在趋化试验中，细菌感染患者的中性粒细胞对趋化刺激的单向运动表现为活性增强，且硝基蓝四氮唑还原通常增加。细菌感染患者的平均趋化指数为165±56，对照组为70±11（P<0.001）。经过7至10天的适当治疗，临床和细菌学反应良好，趋化活性恢复正常。然而，持续存在细菌感染的患者中，趋化反应仍持续亢进。循环中性粒细胞的趋化反应亢进似乎是细菌感染刺激的炎症周期中的一个早期且敏感的事件，可能有助于定位入侵细菌。
