Görög P, Born G V
William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, England.
Microvasc Res. 1995 Jan;49(1):111-6. doi: 10.1006/mvre.1995.1009.
Efflux and extravascular accumulation of intravenously administered fluorescent-labeled low-density lipoprotein (LDL) and albumin were measured in superfused mouse mesenteric preparation in anesthetized mice. Pretreatment of animals with nifedipine (1 and 3 mg/kg sc) significantly reduced both the extravascular accumulation of LDL (measured by fluorescence densitometry) and the efflux (measurement of the tracers in the superfusate) of both LDL and albumin. These effects may help to explain the possible anti-atherogenic effect of nifedipine.
在麻醉小鼠的灌注肠系膜制备物中，测量静脉注射荧光标记的低密度脂蛋白（LDL）和白蛋白的流出及血管外蓄积情况。用硝苯地平（1和3mg/kg皮下注射）预处理动物，可显著降低LDL的血管外蓄积（通过荧光密度测定法测量）以及LDL和白蛋白的流出（测量灌注液中的示踪剂）。这些作用可能有助于解释硝苯地平可能的抗动脉粥样硬化作用。
