Huang R, Hertz L
Department of Pharmacology, University of Saskatchewan, Saskatoon, Canada.
Neurosci Lett. 1995 Jan 2;183(1-2):22-6. doi: 10.1016/0304-3940(94)11106-s.
Phenylsuccinate is an inhibitor of cytosolic glutamate formation from extracellular glutamine in cultured cerebellar granule cell neurons, a glutamatergic preparation. It prevents anoxic cell death in these cells as indicated by decreased lactate dehydrogenase (LDH) release and by the morphological appearance of the cells after the insult. In contrast, it does not prevent neurotoxicity by added glutamate because it is not an antagonist of the glutamate receptor.
苯基琥珀酸盐是培养的小脑颗粒细胞神经元（一种谷氨酸能制剂）中胞质谷氨酸从细胞外谷氨酰胺形成的抑制剂。如乳酸脱氢酶（LDH）释放减少以及损伤后细胞的形态外观所示，它可防止这些细胞发生缺氧性细胞死亡。相比之下，它不能防止添加谷氨酸引起的神经毒性，因为它不是谷氨酸受体的拮抗剂。
