Maeda M, Inoue M, Takao S, Ikegami Y, Nakai M, Krieger A J, Sapru H N, Hayashida Y
Department of Systems Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Neurosci Lett. 1995 Feb 9;185(2):111-4. doi: 10.1016/0304-3940(94)11237-d.
L-Glutamate was microinjected into the nucleus tractus solitarii (NTS) in anesthetized (chloralose and urethane), paralyzed and artificially ventilated rats, and spinal cord blood flow (SCBF) was determined using a combination of labeled microspheres. Unilateral chemical stimulation of the NTS (n = 13) significantly decreased SCBF in the cervical cord from 43 +/- 6 (mean +/- SEM) to 28 +/- 4 (P < 0.05), in the thoracic cord from 35 +/- 3 to 24 +/- 4 (P < 0.01), and in the lumbar cord from 49 +/- 3 to 40 +/- 3 ml min-1 (100 g)-1 (P < 0.05). The decrease in SCBF was not due to the decrease in arterial blood pressure (ABP) because the SCBF during the chemical stimulation of the NTS was significantly smaller (P < 0.05) than the SCBF during controlled hemorrhagic hypotension (n = 11). Chemical stimulation of the NTS did not affect the reactivity of the spinal cord vessels to hypercapnia (n = 5). Microinjection of the vehicle solution into the NTS had no effects on spinal cord circulation (n = 9). These results suggest that the cell bodies within the NTS may play a role in the control of spinal cord circulation.
将L-谷氨酸微量注射到麻醉（水合氯醛和氨基甲酸乙酯）、麻痹并人工通气的大鼠的孤束核（NTS）中，使用标记微球组合测定脊髓血流量（SCBF）。对NTS进行单侧化学刺激（n = 13）可使颈髓的SCBF从43±6（平均值±标准误）显著降低至28±4（P < 0.05），胸髓的SCBF从35±3降至24±4（P < 0.01），腰髓的SCBF从49±3降至40±3 ml·min⁻¹·(100 g)⁻¹（P < 0.05）。SCBF的降低并非由于动脉血压（ABP）的下降，因为在NTS化学刺激期间的SCBF显著小于控制性出血性低血压期间的SCBF（n = 11，P < 0.05）。对NTS的化学刺激不影响脊髓血管对高碳酸血症的反应性（n = 5）。将赋形剂溶液微量注射到NTS中对脊髓循环无影响（n = 9）。这些结果表明，NTS内的细胞体可能在脊髓循环的控制中起作用。
