[Relationship between thrombinemia and free radical processes in the blood].

Thrombin introduced in doses causing disseminated intravascular coagulation (DIC) has been studied for its effect on lipid peroxidation processes (POL) in plasma, erythrocytes and thrombocytes in rats. The vitamin-antioxidant complex is determined to decrease manifestations of DIC and POL intensity. Combined effect on thrombocytes is clearly marked: vitaminization results in diminishing thrombocytopenia caused by thrombinemia and decreasing their aggregation. In vitro thrombin activates POL in blood due to direct contact with erythrocytes and thrombocytes. Thrombocytes are more perceptible to thrombin action. The results analysed suggest that thrombinemia and POL interact as follows: activation of thrombinogenesis causes POL activation resulting in further thrombinogenesis activation etc. We have assumed that an anticoagulant that is not an antioxidant, or an antioxidant that does not directly influence thrombinogenesis may break the cycle or reduce it.