伪狂犬病病毒EPO在功能上与水痘-带状疱疹病毒ORF61蛋白及单纯疱疹病毒1型ICPO同源。
Pseudorabies virus EPO is functionally homologous to varicella-zoster virus ORF61 protein and herpes simplex virus type 1 ICPO.
作者信息
Moriuchi H, Moriuchi M, Dean H, Cheung A K, Cohen J I
机构信息
Medical Virology Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
出版信息
Virology. 1995 May 10;209(1):281-3. doi: 10.1006/viro.1995.1256.
Pseudorabies virus (PRV) early protein O (EPO) is the homolog of varicella-zoster virus (VZV) open reading frame 61 (ORF61) protein and herpes simplex virus type 1 (HSV-1) ICPO. A PRV EPO deletion mutant grows poorly in cell culture, suggesting that EPO plays a critical role in the viral replicative cycle. In this study, we have shown that the growth defect of an EPO deletion mutant was complemented in Vero cells expressing VZV ORF61 protein or HSV-1 ICPO. In transient expression assays PRV EPO, like VZV ORF61 protein and HSV-1 ICPO, transactivates a variety of promoters from PRV, VZV, HSV, and unrelated viruses. These data indicate that PRV EPO is functionally homologous to VZV ORF61 protein and HSV-1 ICPO.
伪狂犬病病毒（PRV）早期蛋白O（EPO）是水痘-带状疱疹病毒（VZV）开放阅读框61（ORF61）蛋白和单纯疱疹病毒1型（HSV-1）感染细胞蛋白O（ICPO）的同源物。PRV EPO缺失突变体在细胞培养中生长不良，这表明EPO在病毒复制周期中起关键作用。在本研究中，我们发现EPO缺失突变体的生长缺陷在表达VZV ORF61蛋白或HSV-1 ICPO的Vero细胞中得到了弥补。在瞬时表达试验中，PRV EPO与VZV ORF61蛋白和HSV-1 ICPO一样，能反式激活来自PRV、VZV、HSV及无关病毒的多种启动子。这些数据表明PRV EPO在功能上与VZV ORF61蛋白和HSV-1 ICPO同源。
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