Dennis A R, Leeson-Payne C G, Hobbs G J
University Department of Anaesthesia, University Hospital, Nottingham.
Anaesthesia. 1995 Apr;50(4):297-9. doi: 10.1111/j.1365-2044.1995.tb04602.x.
A double-blind placebo-controlled study was performed to assess the analgesic effect of rectal sodium diclofenac 100 mg after Caesarean section using subarachnoid hyperbaric bupivacaine 0.5% and morphine 0.2 mg. During the 48 h follow-up period, both placebo and diclofenac groups had comparable analgesia as measured by visual analogue scores (VAS) at rest and on movement. However, diclofenac prolonged the mean time to first analgesia by more than 5 h from 13 h 45 min in the placebo group to 18 h 58 min (p < 0.03). The incidence of side effects (nausea, vomiting, itching, excessive lochia loss and the need for additional analgesia) were comparable in each group.
进行了一项双盲安慰剂对照研究，以评估在剖宫产术后使用0.5%蛛网膜下腔高压布比卡因和0.2mg吗啡的情况下，直肠给予100mg双氯芬酸钠的镇痛效果。在48小时的随访期内，安慰剂组和双氯芬酸钠组在静息和活动时通过视觉模拟评分（VAS）测量的镇痛效果相当。然而，双氯芬酸钠将首次镇痛的平均时间延长了5小时以上，从安慰剂组的13小时45分钟延长至18小时58分钟（p<0.03）。每组副作用（恶心、呕吐、瘙痒、恶露过多和需要额外镇痛）的发生率相当。
