Dreyer E B, Chaturvedi N, Zurakowski D
Glaucoma Consultation Service, Massachusetts Eye and Ear Infirmary, Boston, Mass., USA.
Arch Ophthalmol. 1995 May;113(5):578-80. doi: 10.1001/archopht.1995.01100050044028.
To determine whether there is increased risk to the corneal endothelium when mitomycin C is used in trabeculectomy surgery instead of fluorouracil, and whether these agents play a role in accelerating cataract formation.
DESIGN, SETTINGS, AND PARTICIPANTS: We analyzed the corneal endothelium and the lens preoperatively and postoperatively in 30 eyes of 21 patients who underwent either a fluorouracil- or mitomycin C-supplemented trabeculectomy.
No significant differences were found between these two groups in the rate of cataract progression, magnitude of endothelial cell loss, or appearance of endothelial cell morphologic characteristics. Endothelial cell loss accounted for approximately 7% to 8% of the preoperative counts in both groups. In addition, four (27%) of 15 eyes in each group showed evidence of cataract progression as graded by the Lens Opacities Classification System II.
Fluorouracil- and mitomycin C-supplemented trabeculectomies cause similar changes in the lens and corneal endothelium.
确定小梁切除术使用丝裂霉素C而非氟尿嘧啶时，角膜内皮细胞风险是否增加，以及这些药物是否在加速白内障形成中起作用。
设计、地点和参与者：我们分析了21例接受氟尿嘧啶或丝裂霉素C辅助小梁切除术患者的30只眼睛术前和术后的角膜内皮细胞和晶状体情况。
两组在白内障进展率、内皮细胞丢失量或内皮细胞形态学特征表现方面未发现显著差异。两组内皮细胞丢失量均约占术前计数的7%至8%。此外，每组15只眼中有4只（27%）根据晶状体混浊分类系统II分级显示有白内障进展迹象。
氟尿嘧啶和丝裂霉素C辅助小梁切除术对晶状体和角膜内皮细胞产生相似的变化。
