Pruss D, Hayes J J, Wolffe A P
Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, Bethesda, MD 20892.
Bioessays. 1995 Feb;17(2):161-70. doi: 10.1002/bies.950170211.
The recent surge of discoveries concerning the structural organization of nucleosomes, together with genetic evidence of highly specialized roles for the histones in gene regulation, have brought a renewed need for a detailed understanding of nucleosomal anatomy. Here we review recent structural advances leading to a new level of understanding of the nucleosome and chromatin fibre structure. We discuss the problems and challenges for existing models of chromatin structure and, in particular, consider how linker histones may bind within the nucleosome, together with the implications of their association for the structure of the chromatin fibre.
近期有关核小体结构组织的发现激增，再加上组蛋白在基因调控中具有高度专业化作用的遗传学证据，使得人们再次迫切需要详细了解核小体的结构。在此，我们回顾了近期的结构进展，这些进展使我们对核小体和染色质纤维结构有了新的认识水平。我们讨论了现有染色质结构模型存在的问题和挑战，特别是考虑了连接组蛋白如何在核小体内结合，以及它们的结合对染色质纤维结构的影响。
