Zhukova O V, Anisimov V N
Vopr Onkol. 1994;40(1-3):71-5.
One month-old female rats were blinded by surgery and received single intravenous injections of 50 mg/kg body weight of N-nitrosomethylurea (NMU) two weeks later. Simultaneously, normal animals were injected an identical dose of NMU. The frequency of NMU-induced neoplasms in blind rats was 33% vs. 75% in control (P < 0.05), with neoplastic development latency being longer as compared with controls. The frequency of mammary gland adenocarcinoma, leukemia and adenoma of the pituitary and thyroid gland in blind rats was significantly lower while mammary gland fibroadenoma was more frequent than in intact animals. Carcinogen-treated blind animals survived much longer (448 +/- 21 days) than normal controls (284 +/- 22 days) (P < 0.001). The frequency of spontaneous neoplasms in blind and normal rats was identical. The inhibitory effect on carcinogenesis seems to be due to enhanced functional activity of the pineal gland in blind animals.
1月龄雌性大鼠通过手术致盲，两周后单次静脉注射50mg/kg体重的N-亚硝基甲基脲（NMU）。同时，给正常动物注射相同剂量的NMU。致盲大鼠中NMU诱导肿瘤的发生率为33%，而对照组为75%（P<0.05），与对照组相比，肿瘤发生潜伏期更长。致盲大鼠乳腺腺癌、白血病以及垂体和甲状腺腺瘤的发生率显著降低，而乳腺纤维腺瘤比未致盲动物更常见。经致癌物处理的致盲动物存活时间（448±21天）比正常对照组（284±22天）长得多（P<0.001）。致盲大鼠和正常大鼠自发肿瘤的发生率相同。对致癌作用的抑制作用似乎是由于致盲动物松果体功能活性增强所致。
