Anisimov V N, Zhukova O V, Veniashvili D Sh, Bilanishvili V G, Menabde M Z, Gupta D
Tubingen University, Germany.
Biofizika. 1996 Jul-Aug;41(4):807-14.
Outbred female rats from the age of 1 month were kept at rooms with 12 h light: 12 h dark (LD), 24 h light (LL) and 24 h dark (DD) regimens and 2 weeks later were exposed to 3 weekly i.v. injections of NMU at the dose of 50 mg/kg and starting in 2 days after first NMU administration-to variable or static magnetic fields (VMF and SMF). Exposure to LL regimen significantly promoted whereas the exposure to DD regimen significantly inhibited NMU-induced mammary carcinogenesis. RIA of serum samples from rats maintained under different light regimens has shown that exposure to LL followed by decrease of melatonin level and increase of prolactin level at all of modifying factors (NMU, VMF, SMF). Surgical light deprivation inhibits NMU-indiced mammary carcinogenesis in female rats. The primary role of pineal function in the modifying effects of light/dark regimens and electromagnetic fields on mammary carcinogenesis are suggested.
1月龄的远交系雌性大鼠被饲养在12小时光照：12小时黑暗（LD）、24小时光照（LL）和24小时黑暗（DD）的环境中，2周后每周静脉注射3次剂量为50mg/kg的N-甲基-N-亚硝基脲（NMU），并在首次给予NMU后2天开始暴露于可变或静磁场（VMF和SMF）中。暴露于LL环境显著促进了NMU诱导的乳腺癌发生，而暴露于DD环境则显著抑制了该过程。对处于不同光照环境下的大鼠血清样本进行放射免疫分析（RIA）表明，在所有调节因素（NMU、VMF、SMF）作用下，暴露于LL环境后褪黑素水平降低，催乳素水平升高。手术剥夺光照可抑制雌性大鼠中NMU诱导的乳腺癌发生。提示松果体功能在光照/黑暗环境和电磁场对乳腺癌发生的调节作用中起主要作用。
