Colombo G, Agabio R, Lobina C, Reali R, Melis F, Fadda F, Gessa G L
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Alcohol Alcohol. 1995 Jan;30(1):125-31.
The effect of the dihydropyridine calcium channel antagonist, darodipine, on ethanol withdrawal syndrome was examined in rats made dependent on ethanol by repeated ethanol administration for six consecutive days. Chronic co-administration of darodipine prevented the severity of ethanol withdrawal signs in a dose-dependent fashion. By contrast, acute administration of darodipine during the ethanol withdrawal phase was ineffective in reversing the withdrawal symptoms. The results suggest that the presence of darodipine in the central nervous system during the adaptative responses to ethanol is necessary to reduce the severity of the withdrawal syndrome. They also provide further evidence for a potential clinical usefulness of dihydropyridine calcium channel blockers in treatment of ethanol withdrawal.
通过连续六天重复给予乙醇使大鼠对乙醇产生依赖性，在此基础上研究了二氢吡啶类钙通道拮抗剂达罗地平对乙醇戒断综合征的影响。长期联合使用达罗地平可呈剂量依赖性地减轻乙醇戒断症状的严重程度。相比之下，在乙醇戒断阶段急性给予达罗地平并不能有效逆转戒断症状。结果表明，在对乙醇的适应性反应过程中，中枢神经系统中存在达罗地平对于减轻戒断综合征的严重程度是必要的。它们还为二氢吡啶类钙通道阻滞剂在治疗乙醇戒断方面的潜在临床应用提供了进一步的证据。
