Weill J, Schellenberg F
Laboratoire de Biochimie, C.H.U. Trousseau, Tours, France.
Alcohol Alcohol Suppl. 1993;2:107-10.
The correct clinical interpretation of any laboratory marker requires a good knowledge of its positive and negative predictive values, which are calculated from the sensitivity and the specificity of the test and from the prevalence of the disease. This means that we need a good assay technique in the case of biochemical tests, and a well defined reference sample (control subjects), with the ability to distinguish between a diseased and a healthy subject. In the field of alcohol abuse markers, each of these notions presents some degree of difficulty. There is no perfect solution, and a compromise has to be agreed upon.
对任何实验室指标进行正确的临床解读，都需要充分了解其阳性和阴性预测值，这些值是根据检测的敏感性、特异性以及疾病的患病率计算得出的。这意味着，对于生化检测，我们需要一种良好的检测技术，以及一个定义明确的参考样本（对照受试者），且该样本要有能力区分患病个体和健康个体。在酒精滥用标志物领域，上述每个概念都存在一定程度的困难。不存在完美的解决方案，必须达成一种折衷方案。
