Guerri C, Saez R, Portoles M, Renau-Piqueras J
Inst. Investigaciones Citológicas, Valencia, Spain.
Alcohol Alcohol Suppl. 1993;2:203-8.
We have postulated that the brain alterations observed after "in utero" alcohol exposure could be due, in part, to a direct effect of ethanol on astrogliogenesis. In the present work we summarize the main findings concerning the effect of prenatal exposure to alcohol on astrocytes in primary culture. We have found that this treatment alters astrocyte growth and the content and synthesis of DNA and proteins. However, "in utero" exposure to ethanol also causes important alterations in the astrocyte cytoskeleton which could be related to an alteration in the amount and activity of several plasma membrane glycoproteins. These results agree with ones obtained "in vivo" and suggest that ethanol-induced alterations in astrogliogenesis could be an important mechanism underlying the CNS disfunctions observed after prenatal exposure to ethanol.
我们推测，“子宫内”酒精暴露后观察到的大脑改变，可能部分归因于乙醇对星形胶质细胞生成的直接影响。在本研究中，我们总结了关于产前酒精暴露对原代培养星形胶质细胞影响的主要发现。我们发现这种处理会改变星形胶质细胞的生长以及DNA和蛋白质的含量与合成。然而，“子宫内”乙醇暴露还会导致星形胶质细胞细胞骨架发生重要改变，这可能与几种质膜糖蛋白的数量和活性改变有关。这些结果与“体内”获得的结果一致，表明乙醇诱导的星形胶质细胞生成改变可能是产前乙醇暴露后观察到的中枢神经系统功能障碍的重要潜在机制。
