Comings D E
Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA.
Alcohol Alcohol Suppl. 1993;2:237-41.
Studies of children with ADHD and Tourette syndrome, and their families, show that both the patients and their relatives are at increased risk for alcoholism, and other behavioral disorders. Defective serotonin metabolism has been implicated in all of these disorders. Platelet serotonin and blood tryptophan levels are low in the patients and both parents. Analysis of pedigrees suggest that a gene or genes capable of producing a pleiotrophic spectrum of disorders are inherited from both parents (recessive inheritance), but affected relatives can express some symptoms (dominant inheritance). This suggests an intermediate semirecessive-semidominant inheritance of a common gene affecting serotonin metabolism for ADHD, Tourette syndrome, alcoholism and related disorders. Tryptophan 2,3 dioxygenase (TDO2) is suggested as a possible candidate gene.
对患有注意力缺陷多动障碍（ADHD）和抽动秽语综合征的儿童及其家庭的研究表明，患者及其亲属患酒精中毒和其他行为障碍的风险增加。血清素代谢缺陷与所有这些疾病都有关联。患者及其父母的血小板血清素和血液色氨酸水平都很低。系谱分析表明，能够产生多效性疾病谱的一个或多个基因是从父母双方遗传而来的（隐性遗传），但受影响的亲属可能会表现出一些症状（显性遗传）。这表明影响血清素代谢的一个共同基因存在中间半隐性-半显性遗传，涉及注意力缺陷多动障碍、抽动秽语综合征、酒精中毒及相关疾病。色氨酸2,3双加氧酶（TDO2）被认为是一个可能的候选基因。
