Phillips T J
Veterans Affairs Medical Center, Portland, OR, USA.
Alcohol Alcohol Suppl. 1993;2:451-5.
Alcohol-induced locomotor stimulation in mice may provide an animal model of human euphoric responses to moderate alcohol (ethanol) doses. If a common mechanism mediates sensitivity to both drug reward (reinforcement) and drug stimulation, rodent models of drug stimulation would provide powerful tools for investigating drug reinforcement. In addition, stimulant sensitivity might provide a simple marker for susceptibility to ethanol reward, and perhaps addiction (e.g., Newlin and Thomson, 1991). This short report describes the use of three genetic mouse models, (1) FAST and SLOW selectively bred lines, (2) BXD Recombinant Inbred Strains, and (3) a panel of inbred strains of diverse genetic origin, to explore mechanisms mediating ethanol stimulation and reinforcement.
酒精诱导的小鼠运动兴奋可能为人类对适度酒精（乙醇）剂量产生欣快感反应提供一种动物模型。如果存在一种共同机制介导对药物奖赏（强化）和药物刺激的敏感性，那么药物刺激的啮齿动物模型将为研究药物强化提供强大工具。此外，兴奋剂敏感性可能为乙醇奖赏易感性，甚至成瘾性（例如，纽林和汤姆森，1991年）提供一个简单的标志物。本简短报告描述了使用三种基因小鼠模型，（1）快速和慢速选择性培育品系，（2）BXD重组近交系，以及（3）一组具有不同遗传起源的近交系，来探索介导乙醇刺激和强化的机制。
