Abel E L
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Alcohol. 1995 Jan-Feb;12(1):1-6. doi: 10.1016/0741-8329(94)00058-l.
Male rats were intubated with either 5, 2.5, or 0 g/kg alcohol. Animals in the latter two groups were pairfed to those in the 5 g/kg group. A fourth group of males was not treated and was fed ad lib. Males were bred once after 3 weeks of intubation and twice after 9 weeks of intubation. Females in the first two breedings were sacrificed prior to delivery, whereas females in the last breeding were allowed to deliver their litters. There were no significant decreases in male fertility or litter size, but fecundity was reduced in females bred to alcohol-treated males when all breedings were pooled. Newborn weights (third breeding) were not significantly affected by paternal alcohol treatment, but fetal weights in the first two breedings were significantly increased in association with paternal alcohol treatment. There was also an alcohol-related increase in the number of male fetuses in breeding one, and an increase in placental weights in breeding two; the placental index (placental weight/fetal weight) was also decreased by paternal alcohol treatment for fetuses in the second breeding. These results suggest paternal alcohol treatment can have effects on offspring body weights, which are not observable once females have given birth.
雄性大鼠分别经口给予5、2.5或0 g/kg酒精。后两组动物与给予5 g/kg酒精的组进行配对饲养。第四组雄性大鼠不进行处理，自由进食。插管3周后雄性大鼠繁殖一次，插管9周后繁殖两次。前两次繁殖中的雌性大鼠在分娩前处死，而最后一次繁殖中的雌性大鼠则让其产仔。雄性生育力或窝仔数没有显著下降，但当所有繁殖情况汇总时，与经酒精处理的雄性大鼠交配的雌性大鼠的繁殖力降低。新生仔鼠体重（第三次繁殖）不受父本酒精处理的显著影响，但前两次繁殖中的胎儿体重与父本酒精处理相关显著增加。第一次繁殖中雄性胎儿数量也有与酒精相关的增加，第二次繁殖中胎盘重量增加；父本酒精处理也使第二次繁殖中胎儿的胎盘指数（胎盘重量/胎儿重量）降低。这些结果表明，父本酒精处理可对后代体重产生影响，雌性大鼠分娩后这些影响就无法观察到了。
