Abel E L, Tan S E
Department of Obstetrics/Gynecology, Wayne State University, Detroit, MI 48201.
Neurotoxicol Teratol. 1988 May-Jun;10(3):187-92. doi: 10.1016/0892-0362(88)90016-5.
Male rats were divided into 3 groups and were given ad lib access to a liquid alcohol diet containing 35% ethanol derived calories (EDC) or were pair-fed with an isocaloric control diet, containing 17.5% or 0% EDC, for a minimum of 52 days. A fourth group was fed rat chow ad lib. Males were then mated with non-treated females. Males consuming alcohol did not differ in sexual behavior but were less fertile and sired offspring that were significantly less active than controls and the effects on activity were dose-related. Females sired by males consuming alcohol also performed worse in a two-way shock avoidance learning task although differences in this task were not dose-related. There were no significant effects, however, on body weight of offspring at birth or at 21 days of age or on other behavioral measures such as spontaneous alternation or passive avoidance learning.
雄性大鼠被分为3组，自由摄取含35%乙醇热量（EDC）的液体酒精饮食，或与含17.5%或0% EDC的等热量对照饮食配对喂养至少52天。第四组自由采食大鼠饲料。然后将雄性大鼠与未处理的雌性大鼠交配。饮酒的雄性大鼠在性行为方面没有差异，但生育能力较低，所生后代的活跃度明显低于对照组，且对活动的影响与剂量相关。由饮酒雄性大鼠所生的雌性大鼠在双向回避电击学习任务中的表现也较差，不过该任务中的差异与剂量无关。然而，对出生时或21日龄后代的体重，或对其他行为指标，如自发交替或被动回避学习，均无显著影响。
