Alfonso V, González-Granda D, Alonso C, Ponce J, Bixquert M, Oltra C, Roig E, Ortuño J A
Sección de Aparato Digestivo, Hospital Lluis Alcanyis, Xátiva, Valencia.
Rev Esp Enferm Dig. 1995 Feb;87(2):109-13.
The prevalence of IgG antibodies to Helicobacter pylori was determined with an enzyme-linked immunosorbent assay in 80 families who lived together with 40 duodenal ulcer patients in whom Helicobacter pylori had been cultured from a gastric biopsy (34 spouses, 31 children, 10 parents, 4 sisters and 1 brother) and in 112 controls from the same habitat and with similar age. The antibodies were positive in 38.4% of the relatives and in 36.6% of the controls, the difference was not significant. Among spouses of patients, 38.4% of those aged 25-39 years and 66.6% of those aged 40-67 years were positive, whereas controls showed a 29.2% and a 58.3% of positives respectively. The differences between both groups were not significant. Among children, 17.2% were positive and in parents 50%, whereas among controls with a similar age 26.3% and 62.5% respectively were positive. The differences between relatives and controls were not significant. We conclude that in our environment among consanguineous families living together and between spouses, person-to-person spread of Helicobacter pylori does not usually occur or it happens uncommonly.
采用酶联免疫吸附测定法，对与40例十二指肠溃疡患者共同生活的80个家庭（34名配偶、31名子女、10名父母、4名姐妹和1名兄弟，这些十二指肠溃疡患者的胃活检标本中培养出了幽门螺杆菌）以及来自同一居住环境、年龄相仿的112名对照者，测定了幽门螺杆菌IgG抗体的流行情况。亲属中抗体阳性率为38.4%，对照者中为36.6%，差异无统计学意义。在患者配偶中，25 - 39岁年龄段者阳性率为38.4%，40 - 67岁年龄段者为66.6%，而对照者中相应年龄段的阳性率分别为29.2%和58.3%。两组之间的差异无统计学意义。在子女中，阳性率为17.2%，父母中为50%，而在年龄相仿的对照者中，相应阳性率分别为26.3%和62.5%。亲属与对照者之间的差异无统计学意义。我们得出结论，在我们所处的环境中，在共同生活的有血缘关系的家庭以及配偶之间，幽门螺杆菌通常不会发生人际传播，或者传播情况不常见。
