Lieverse R J, Masclee A A, Jansen J B, Rovati L C, Lamers C B
Department of Gastroenterology and Hepatology, University Hospital of Leiden, The Netherlands.
Biol Psychiatry. 1995 Mar 1;37(5):331-5. doi: 10.1016/0006-3223(94)00136-Q.
Several studies have demonstrated that administration of cholecystokinin (CCK) reduces food intake in several species, including humans. In animal studies CCK-receptor antagonists have been reported to increase food intake, suggesting a physiological satiety effect of CCK in these animals. In a double-blind, placebo-controlled study, we investigated the effect of the specific CCK-A receptor antagonist loxiglumide on food intake (carbohydrate-rich meal) and on subjective hunger feelings scored with visual analogue scales and food selection lists in seven healthy obese women and in seven healthy lean women. Loxiglumide was administered intravenously in a dose of 10 mg/kg ideal weight/h. For the whole group, food intake during loxiglumide (359 +/- 39 g) was not significantly different from food intake during saline infusion (333 +/- 31 g). Also, when the lean and obese subgroups were analyzed separately, no significant influence of loxiglumide on food intake was found. In addition, no significant differences in satiety scores were seen using the food selection lists or visual analogue scales. In conclusion, in the present study during infusing the CCK-A receptor antagonist loxiglumide we found no increase in preprandial satiety nor in food intake of a carbohydrate-rich meal nor in postprandial satiety in lean and obese women.
多项研究表明，给予胆囊收缩素（CCK）可减少包括人类在内的多种物种的食物摄入量。在动物研究中，据报道CCK受体拮抗剂会增加食物摄入量，这表明CCK在这些动物中具有生理饱腹感作用。在一项双盲、安慰剂对照研究中，我们调查了特异性CCK - A受体拮抗剂洛西格列胺对7名健康肥胖女性和7名健康瘦女性的食物摄入量（富含碳水化合物的餐食）以及用视觉模拟量表和食物选择清单评分的主观饥饿感的影响。洛西格列胺以10 mg/kg理想体重/小时的剂量静脉给药。对于整个组，洛西格列胺给药期间的食物摄入量（359±39克）与生理盐水输注期间的食物摄入量（333±31克）无显著差异。此外，当分别分析瘦女性和肥胖女性亚组时，未发现洛西格列胺对食物摄入量有显著影响。另外，使用食物选择清单或视觉模拟量表时，饱腹感评分也无显著差异。总之，在本研究中，在输注CCK - A受体拮抗剂洛西格列胺期间，我们发现瘦女性和肥胖女性的餐前饱腹感、富含碳水化合物餐食的食物摄入量以及餐后饱腹感均未增加。
