Brewer G J
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48103, USA.
Nutrition. 1995 Jan-Feb;11(1 Suppl):114-6.
We review two newer treatments for Wilson's disease that each use an interaction of another metal with Cu to bring about therapeutic benefit. The two metals are Zn, in the form of the acetate salt, and Mo in the form of ammonium tetrathiomolybdate (TM). Zn, which blocks absorption of Cu in the intestine by inducing intestinal cell metallothionein, is used for maintenance therapy, treatment of the presymptomatic patient from the beginning, and treatment of the pregnant patient. TM, which complexes Cu in a tripartite complex with protein, is used for the initial treatment of neurologically presenting patients.
我们回顾了两种治疗威尔逊氏病的新疗法，它们均利用另一种金属与铜的相互作用来产生治疗效果。这两种金属分别是醋酸盐形式的锌和四硫代钼酸铵（TM）形式的钼。锌通过诱导肠细胞金属硫蛋白来阻断肠道对铜的吸收，用于维持治疗、从一开始就对症状前患者进行治疗以及对孕妇进行治疗。TM能与蛋白质形成三方复合物来络合铜，用于对出现神经症状患者的初始治疗。
