Wassarman D A, Therrien M, Rubin G M
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley 94720-3200, USA.
Curr Opin Genet Dev. 1995 Feb;5(1):44-50. doi: 10.1016/s0959-437x(95)90052-7.
During Drosophila eye development, a Ras cascade mediates the decision between neuronal and non-neuronal differentiation of the R7 photoreceptor precursor. Recent genetic and molecular studies have identified a set of protein kinases as components of the Ras cascade and nuclear targets of the cascade, including Yan, Pointed, Jun, and Phyllopod. The Ras cascade functions in other Drosophila signal transduction pathways, eliciting a distinct response in each case, presumably through phosphorylation of specific transcription factors.
在果蝇眼睛发育过程中，一条Ras信号级联反应介导R7光感受器前体细胞的神经元分化和非神经元分化之间的抉择。最近的遗传学和分子研究已经鉴定出一组蛋白激酶作为Ras信号级联反应的组成部分以及该信号级联反应的核靶点，包括Yan、Pointed、Jun和叶足蛋白。Ras信号级联反应在果蝇的其他信号转导途径中发挥作用，大概是通过特定转录因子的磷酸化作用，在每种情况下引发不同的反应。
